Medical Publishing

Treatment

The Ebola virus, like all viruses “hot”, no cure and no specific treatment. The treatment used today is to maintain the life of the person by methods of resuscitation (CPR, artificial respiration) and control bleeding as far as possible.

As for a vaccine, investigations are underway but these are complicated because we still do not know all the proteins of the virus and because there are only 2 or three laboratories equipped to work with a virus such as these.

These laboratories are located in the U.S. and Russia, and the best known are the CDC (Centers for Disease Control) in Atlanta, Georgia, and USAMRIID (United Estates Infectius Army Medical Research of Diseases, Research Center for Infectious Diseases Army U.S. rough translation).

The Soviet Union (Russia) to manipulate this virus for military purposes, it is easy to reproduce in laboratories, highly efficient aerosol, highly contagious Ebola mortality can reach 90%, and most important is that there is no specific treatment.

Calif.. CDC and known outbreaks

This virus has been classified by the Centers for Disease Control and Level 4 Security-biohazardous. This means that for those in Level 4 (hotspot) to use maximum caution biological (use of biohazard suits, similar to those of astronauts, three pairs of gloves and the environment should be most effective filters for air and waste. Also after working at Level 4 should enter the decontamination shower (called gray zone) which is a 7 minute shower which is sprayed with the most potent chemicals and disinfectants. We are not working at Level 4 until one has years of experience.

The first place was identified was a co-epidemic in Zaire (now Democratic Republic of Congo) and Sudan. The strain of Zaire is the deadliest in nearly 90%. The Sudan had a 60%, about 30% less, but quickly expanded. These were the most significant outbreaks. There have been outbreaks in England, Sweden, Côte d’Ivoire (Ivory Coast), and the U.S.. All had fewer than 10 cases and almost no deaths occurred. The most significant outbreaks: RDC (the place of first outbreak), Sudan (also where the first outbreak occurred), Congo, Gabon and Uganda.

They discover how Ebola virus infects cells

(NC & T) The Ebola virus reproduction in laboratory-grown cells is severely hampered by certain chemicals that inhibit enzymes, according to a team of experts whose research has been supported by the National Institute of Allergy and Infectious Diseases (NIAID), part National Institutes of Health (NIH).

The researchers identified two cellular enzymes Ebola virus needs to reproduce. When those enzymes are blocked, the virus loses most of its infectivity.

Ebola virus, like the Marburg virus now alarming Angola, is a filovirus, a family of viruses that cause severe hemorrhagic fevers, and often fatal. Finding medical countermeasures for viral hemorrhagic fevers is a priority for global public health, not only because these diseases occur naturally, but also because, according to Elias A. alert Zerhouni, NIH director, could be used for bioterrorism.

This research sheds light on the mechanisms of Ebola virus uses to enter cells. Anthony S. Fauci, NIAID director, is convinced that the findings raise the possibility of a broad-spectrum antiviral therapy that could be effective against multiple hemorrhagic fever viruses.

The study’s lead author, James M. Cunningham, Brigham and Women’s Hospital and Harvard Medical School in Boston and his colleagues discovered two cellular enzymes Ebola virus uses to choose and cut up one of the viral surface proteins. Once this protein is snipped apart, the virus is free to begin multiplying. The scientists applied broad-spectrum enzyme inhibitors to mammalian cells before exposing them to Ebola virus. When one specific cellular enzyme, cathepsin B, was inhibited, the infectivity of Ebola virus dropped to near zero. Another enzyme, cathepsin L, also demonstrated an important role in the infection process.

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